Institute of Biological and Chemical Systems - Biological Information Processing

Publications 2020


  1. The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
    Klems, A.; van Rijssel, J.; Ramms, A. S.; Wild, R.; Hammer, J.; Merkel, M.; Derenbach, L.; Préau, L.; Hinkel, R.; Suarez-Martinez, I.; Schulte-Merker, S.; Vidal, R.; Sauer, S.; Kivelä, R.; Alitalo, K.; Kupatt, C.; van Buul, J. D.; le Noble, F.
    2020. Nature Communications, 11 (1), Art.-Nr. 5319. doi:10.1038/s41467-020-19008-0Full textFull text of the publication as PDF document
  2. Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function.
    Stanicek, L.; Lozano-Vidal, N.; Bink, D. I.; Hooglugt, A.; Yao, W.; Wittig, I.; van Rijssel, J.; van Buul, J. D.; van Bergen, A.; Klems, A.; Ramms, A. S.; Le Noble, F.; Hofmann, P.; Szulcek, R.; Wang, S.; Offermanns, S.; Ercanoglu, M. S.; Kwon, H.-B.; Stainier, D.; Huveneers, S.; Kurian, L.; Dimmeler, S.; Boon, R. A.
    2020. Communications biology, 3 (1), Art.Nr. 265. doi:10.1038/s42003-020-0987-0Full textFull text of the publication as PDF document
  3. Automated high-throughput heartbeat quantification in medaka and zebrafish embryos under physiological conditions.
    Gierten, J.; Pylatiuk, C.; Hammouda, O. T.; Schock, C.; Stegmaier, J.; Wittbrodt, J.; Gehrig, J.; Loosli, F.
    2020. Scientific reports, 10 (1), Article no: 2046. doi:10.1038/s41598-020-58563-wFull textFull text of the publication as PDF document
  4. Inhalable aerosols from carbon fibres.
    Mülhopt, S.; Hauser, M.; Wexler, M.; Baumann, W.; Diebaté, S.; Fritsch-Decker, S.; Weiss, C.; Friesen, A.; Hufnagel, M.; Hartwig. Andrea; Gutmann, B.; Schlager, C.; Krebs, T.; Goßmann, A.-K.; Weis, F.; Stapf, D.
    2020. doi:10.5445/IR/1000125510
  5. Brownian motion-based nanoparticle sizing - A powerful approach for in situ analysis of nanoparticle-protein interactions.
    Nienhaus, K.; Nienhaus, G. U.
    2020. Biointerphases, 15 (6), Article no: 061201. doi:10.1116/6.0000438
  6. Remembering Paolo: A tribute to Paolo Sassone-Corsi.
    Foulkes, N. S.; Eckel-Mahan, K.; Cermakian, N.
    2020. Journal of pineal research, 69 (4), Art.Nr. e12692. doi:10.1111/jpi.12692
  7. Sociocultural incentives for cancer care implementation.
    Haier, J.; Sleeman, J.; Schäfers, J.
    2020. Clinical & experimental metastasis, 37 (5), 561–563. doi:10.1007/s10585-020-10050-2Full textFull text of the publication as PDF document
  8. EGFR/Ras-induced CCL20 production modulates the tumour microenvironment.
    Hippe, A.; Braun, S. A.; Oláh, P.; Gerber, P. A.; Schorr, A.; Seeliger, S.; Holtz, S.; Jannasch, K.; Pivarcsi, A.; Buhren, B.; Schrumpf, H.; Kislat, A.; Bünemann, E.; Steinhoff, M.; Fischer, J.; Lira, S. A.; Boukamp, P.; Hevezi, P.; Stoecklein, N. H.; Hoffmann, T.; Alves, F.; Sleeman, J.; Bauer, T.; Klufa, J.; Amberg, N.; Sibilia, M.; Zlotnik, A.; Müller-Homey, A.; Homey, B.
    2020. British journal of cancer, 123 (6), 942–954. doi:10.1038/s41416-020-0943-2
  9. A cautionary note: Toxicity of polyethylene glycol 200 injected intraperitoneally into mice.
    Thiele, W.; Kyjacova, L.; Köhler, A.; Sleeman, J. P.
    2020. Laboratory animals, 54 (4), 391–396. doi:10.1177/0023677219873684
  10. Assessment of incentivizing effects for cancer care frameworks.
    Haier, J.; Sleeman, J.; Schäfers, J.
    2020. Clinical & experimental metastasis, 37 (4), 447–450. doi:10.1007/s10585-020-10046-y
  11. Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves.
    Takamiya, M.; Stegmaier, J.; Kobitski, A. Y.; Schott, B.; Weger, B. D.; Margariti, D.; Cereceda Delgado, A. R.; Gourain, V.; Scherr, T.; Yang, L.; Sorge, S.; Otte, J. C.; Hartmann, V.; Wezel, J. van; Stotzka, R.; Reinhard, T.; Schlunck, G.; Dickmeis, T.; Rastegar, S.; Mikut, R.; Nienhaus, G. U.; Strähle, U.
    2020. PLoS Genetics, 16 (6), Art. Nr.: e1008774. doi:10.1371/journal.pgen.1008774Full textFull text of the publication as PDF document
  12. Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance.
    Nwosu, Z. C.; Piorońska, W.; Battello, N.; Zimmer, A. D.; Dewidar, B.; Han, M.; Pereira, S.; Blagojevic, B.; Castven, D.; Charlestin, V.; Holenya, P.; Lochead, J.; De La Torre, C.; Gretz, N.; Sajjakulnukit, P.; Zhang, L.; Ward, M. H.; Marquardt, J. U.; di Magliano, M. P.; Lyssiotis, C. A.; Sleeman, J.; Wölfl, S.; Ebert, M. P.; Meyer, C.; Hofmann, U.; Dooley, S.
    2020. EBioMedicine, 54, Art.Nr.: 102699. doi:10.1016/j.ebiom.2020.102699Full textFull text of the publication as PDF document
  13. Toxicity of mercury: Molecular evidence.
    Yang, L.; Zhang, Y.; Wang, F.; Luo, Z.; Guo, S.; Strähle, U.
    2020. Chemosphere, 245, 125586. doi:10.1016/j.chemosphere.2019.125586
  14. Toxicity assessment of pristine and thermally treated carbon fibres.
    Diabaté, S.; Fritsch-Decker, S.; Mülhopt, S.; Wexler, M.; Hauser, M.; Baumann, W.; Hufnagel, M.; Friesen, A.; Hartwig, A.; Stapf, D.; Weiss, C.
    2020. Naunyn-Schmiedeberg’s archives of pharmacology, 393 (S1), S89. doi:10.1007/s00210-020-01828-y
  15. The contribution of platelets to intravascular arrest, extravasation, and outgrowth of disseminated tumor cells.
    Foss, A.; Muñoz-Sagredo, L.; Sleeman, J.; Thiele, W.
    2020. Clinical & experimental metastasis, 37 (1), 47–67. doi:10.1007/s10585-019-10009-y
  16. Toxicology and Risk Assessment: A Comprehensive Introduction, 2nd Edition. Edited by Helmut Greim and Robert Snyder.
    Dietrich, C.; Weiss, C.
    2020. ChemMedChem, 15 (1), 172. doi:10.1002/cmdc.201900586
  17. Human innate immune cell crosstalk induces melanoma cell senescence.
    Funck, F.; Pahl, J.; Kyjacova, L.; Freund, L.; Oehrl, S.; Gräbe, G.; Pezer, S.; Hassel, J. C.; Sleeman, J.; Cerwenka, A.; Schäkel, K.
    2020. OncoImmunology, 9 (1), Article-Nr.: 1808424. doi:10.1080/2162402X.2020.1808424
  18. Correction to: Gene duplication and functional divergence of the zebrafish otospiralin genes.
    Baanannou, A.; Rastegar, S.; Bouzid, A.; Takamiya, M.; Gerber, V.; Souissi, A.; Beil, T.; Jrad, O.; Strähle, U.; Masmoudi, S.
    2020. Development genes and evolution, 230 (1), 37. doi:10.1007/s00427-020-00647-8
  19. epiTracker: A Framework for Highly Reliable Particle Tracking for the Quantitative Analysis of Fish Movements in Tanks.
    Bruch, R.; Scheikl, P. M.; Mikut, R.; Loosli, F.; Reischl, M.
    2020. SLAS technology. doi:10.1177/2472630320977454
  20. Application of ethyl cinnamate based optical tissue clearing and expansion microscopy combined with retrograde perfusion for 3D lung imaging.
    Sun, Q.; Picascia, T.; Khan, A. ul M.; Brenna, C.; Heuveline, V.; Schmaus, A.; Sleeman, J. P.; Gretz, N.
    2020. Experimental lung research, 1–16. doi:10.1080/01902148.2020.1829183
  21. RASSF1A Suppresses Estrogen-Dependent Breast Cancer Cell Growth through Inhibition of the Yes-Associated Protein 1 (YAP1), Inhibition of the Forkhead Box Protein M1 (FOXM1), and Activation of Forkhead Box Transcription Factor 3A (FOXO3A).
    Roßwag, S.; Thiede, G.; Sleeman, J. P.; Thaler, S.
    2020. Cancers, 12 (9), Art. Nr.: 2689. doi:10.3390/cancers12092689Full textFull text of the publication as PDF document
  22. Genetically encoded thiol redox-sensors in the zebrafish model: Lessons for embryonic development and regeneration.
    Breus, O.; Dickmeis, T.
    2020. Biological chemistry, 402 (3), 363–378. doi:10.1515/hsz-2020-0269
  23. Development of Open-Field Behaviour in the Medaka, Oryzias latipes.
    Lucon-Xiccato, T.; Conti, F.; Loosli, F.; Foulkes, N. S.; Bertolucci, C.
    2020. Biology, 9 (11), Article: 389. doi:10.3390/biology9110389Full textFull text of the publication as PDF document
  24. The Genetic Programs Specifying Kolmer–Agduhr Interneurons.
    Yang, L.; Wang, F.; Strähle, U.
    2020. Frontiers in neuroscience, 14, Art.-Nr.: 577879. doi:10.3389/fnins.2020.577879Full textFull text of the publication as PDF document
  25. MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly.
    Weger, M.; Weger, B. D.; Schink, A.; Takamiya, M.; Stegmaier, J.; Gobet, C.; Parisi, A.; Kobitski, A. Y.; Mertes, J.; Krone, N.; Strähle, U.; Nienhaus, G. U.; Mikut, R.; Gachon, F.; Gut, P.; Dickmeis, T.
    2020. eLife, 9, Art. Nr. e57068. doi:10.7554/eLife.57068Full textFull text of the publication as PDF document
  26. Introducing Biomedisa as an open-source online platform for biomedical image segmentation.
    Lösel, P. D.; Van de Kamp, T.; Jayme, A.; Ershov, A.; Faragó, T.; Pichler, O.; Tan Jerome, N.; Aadepu, N.; Bremer, S.; Chilingaryan, S. A.; Heethoff, M.; Kopmann, A.; Odar, J.; Schmelzle, S.; Zuber, M.; Wittbrodt, J.; Baumbach, T.; Heuveline, V.
    2020. Nature Communications, 11 (1), Article no: 5577. doi:10.1038/s41467-020-19303-wFull textFull text of the publication as PDF document
  27. Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals.
    Diotel, N.; Lübke, L.; Strähle, U.; Rastegar, S.
    2020. Frontiers in neuroscience, 14, Art.-Nr.: 568930. doi:10.3389/fnins.2020.568930Full textFull text of the publication as PDF document
  28. One‐Step Fabrication of Perovskite‐Based Upconversion Devices.
    Wieghold, S.; Bieber, A. S.; Lackner, J.; Nienhaus, K.; Nienhaus, G. U.; Nienhaus, L.
    2020. ChemPhotoChem, 4 (9), 704–712. doi:10.1002/cptc.202000068
  29. Improving quality in nanoparticle-induced cytotoxicity testing by a tiered inter-laboratory comparison study.
    Nelissen, I.; Haase, A.; Anguissola, S.; Rocks, L.; Jacobs, A.; Willems, H.; Riebeling, C.; Luch, A.; Piret, J.-P.; Toussaint, O.; Trouiller, B.; Lacroix, G.; Gutleb, A. C.; Contal, S.; Diabaté, S.; Weiss, C.; Lozano-Fernández, T.; González-Fernández, Á.; Dusinska, M.; Huk, A.; Stone, V.; Kanase, N.; Nocuń, M.; Stępnik, M.; Meschini, S.; Ammendolia, M. G.; Lewinski, N.; Riediker, M.; Venturini, M.; Benetti, F.; Topinka, J.; Brzicova, T.; Milani, S.; Rädler, J.; Salvati, A.; Dawson, K. A.
    2020. Nanomaterials, 10 (8), Art.Nr. 1430. doi:10.3390/nano10081430Full textFull text of the publication as PDF document
  30. Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic.
    Weiss, C.; Carriere, M.; Fusco, L.; Capua, I.; Regla-Nava, J. A.; Pasquali, M.; Scott, J. A.; Vitale, F.; Unal, M. A.; Mattevi, C.; Bedognetti, D.; Merkoçi, A.; Tasciotti, E.; Yilmazer, A.; Gogotsi, Y.; Stellacci, F.; Delogu, L. G.
    2020. ACS nano, 14 (6), 6383–6406. doi:10.1021/acsnano.0c03697
  31. Influence of wood species on toxicity of log-wood stove combustion aerosols: A parallel animal and air-liquid interface cell exposure study on spruce and pine smoke.
    Ihantola, T.; Di Bucchianico, S.; Happo, M.; Ihalainen, M.; Uski, O.; Bauer, S.; Kuuspalo, K.; Sippula, O.; Tissari, J.; Oeder, S.; Hartikainen, A.; Rönkkö, T. J.; Martikainen, M.-V.; Huttunen, K.; Vartiainen, P.; Suhonen, H.; Kortelainen, M.; Lamberg, H.; Leskinen, A.; Sklorz, M.; Michalke, B.; Dilger, M.; Weiss, C.; Dittmar, G.; Beckers, J.; Irmler, M.; Buters, J.; Candeias, J.; Czech, H.; Yli-Pirilä, P.; Abbaszade, G.; Jakobi, G.; Orasche, J.; Schnelle-Kreis, J.; Kanashova, T.; Karg, E.; Streibel, T.; Passig, J.; Hakkarainen, H.; Jokiniemi, J.; Zimmermann, R.; Hirvonen, M.-R.; Jalava, P. I.
    2020. Particle and fibre toxicology, 17 (1), Article: 27. doi:10.1186/s12989-020-00355-1Full textFull text of the publication as PDF document
  32. Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy.
    Eckert, A. F.; Gao, P.; Wesslowski, J.; Wang, X.; Rath, J.; Nienhaus, K.; Davidson, G.; Nienhaus, G. U.
    2020. eLife, 9, Article No. e55286. doi:10.7554/eLife.55286Full textFull text of the publication as PDF document
  33. Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish.
    Bosze, B.; Ono, Y.; Mattes, B.; Sinner, C.; Gourain, V.; Thumberger, T.; Tlili, S.; Wittbrodt, J.; Saunders, T. E.; Strähle, U.; Schug, A.; Scholpp, S.
    2020. Histochemistry and cell biology, 154, 463–480. doi:10.1007/s00418-020-01887-5Full textFull text of the publication as PDF document
  34. Expression of a Barhl1a reporter in subsets of retinal ganglion cells and commissural neurons of the developing zebrafish brain.
    Albadri, S.; Armant, O.; Aljand-Geschwill, T.; Del Bene, F.; Carl, M.; Strähle, U.; Poggi, L.
    2020. Scientific reports, 10 (1), Art. Nr.: 8814. doi:10.1038/s41598-020-65435-wFull textFull text of the publication as PDF document
  35. Proteasome subunit variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress.
    Kröll‐Hermi, A.; Ebstein, F.; Stoetzel, C.; Geoffroy, V.; Schaefer, E.; Scheidecker, S.; Bär, S.; Takamiya, M.; Kawakami, K.; Zieba, B. A.; Studer, F.; Pelletier, V.; Eyermann, C.; Speeg‐Schatz, C.; Laugel, V.; Lipsker, D.; Sandron, F.; McGinn, S.; Boland, A.; Deleuze, J.; Kuhn, L.; Chicher, J.; Hammann, P.; Friant, S.; Etard, C.; Krüger, E.; Muller, J.; Strähle, U.; Dollfus, H.
    2020. EMBO molecular medicine, 12 (7), Art. Nr.: e11861. doi:10.15252/emmm.201911861Full textFull text of the publication as PDF document
  36. Bone morphogenetic protein signaling regulates Id1-mediated neural stem cell quiescence in the adult zebrafish brain via a phylogenetically conserved enhancer module.
    Zhang, G.; Ferg, M.; Lübke, L.; Takamiya, M.; Beil, T.; Gourain, V.; Diotel, N.; Strähle, U.; Rastegar, S.
    2020. Stem cells, 38, 875–889. doi:10.1002/stem.3182Full textFull text of the publication as PDF document
  37. Nano Meets Micro-Translational Nanotechnology in Medicine: Nano-Based Applications for Early Tumor Detection and Therapy.
    Siemer, S.; Wünsch, D.; Khamis, A.; Lu, Q.; Scherberich, A.; Filippi, M.; Krafft, M. P.; Hagemann, J.; Weiss, C.; Ding, G.-B.; Stauber, R. H.; Gribko, A.
    2020. Nanomaterials, 10 (2), 383. doi:10.3390/nano10020383Full textFull text of the publication as PDF document
  38. Guidance of healthcare development for metastatic cancer patients as an example for setting incentives.
    Haier, J.; Sleeman, J.; Schäfers, J.
    2020. Clinical & experimental metastasis, 37 (1), 1–5. doi:10.1007/s10585-019-10014-1
  39. Differential Nanoparticle Sequestration by Macrophages and Scavenger Endothelial Cells Visualized in Real-Time and at Ultrastructural Resolution.
    Hayashi, Y.; Takamiya, M.; Jensen, P. B.; Ojea-Jiménez, I.; Claude, H.; Antony, C.; Kjaer-Sorensen, K.; Grabher, C.; Boesen, T.; Gilliland, D.; Oxvig, C.; Straehle, U.; Weiss, C.
    2020. ACS nano, 14 (2), 1665–1681. doi:10.1021/acsnano.9b07233
  40. Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos.
    Afonin, S.; Babii, O.; Reuter, A.; Middel, V.; Takamiya, M.; Strähle, U.; Komarov, I. V.; Ulrich, A. S.
    2020. Beilstein journal of organic chemistry, 16, 39–49. doi:10.3762/bjoc.16.6Full textFull text of the publication as PDF document
  41. Self-assembled thermosensitive luminescent nanoparticles with peptide-Au conjugates for cellular imaging and drug delivery.
    Zhang, X.; Liu, W.; Wang, H.; Zhao, X.; Zhang, Z.; Nienhaus, G. U.; Shang, L.; Su, Z.
    2020. Chinese chemical letters, 31 (3), 859–864. doi:10.1016/j.cclet.2019.06.032