Publications 2022


  1. Development of a small molecule BAG1 inhibitor for estrogen receptor positive breast cancer therapy. PhD dissertation
    Pan, M.
    2022, December 1. Karlsruher Institut für Technologie (KIT). doi:10.5445/IR/1000152551
  2. Comparison of anxiety-like and social behaviour in medaka and zebrafish
    Lucon-Xiccato, T.; Loosli, F.; Conti, F.; Foulkes, N. S.; Bertolucci, C.
    2022. Scientific Reports, 12 (1), Art.Nr. 10926. doi:10.1038/s41598-022-14978-1Full textFull text of the publication as PDF document
  3. Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
    Prummel, K. D.; Crowell, H. L.; Nieuwenhuize, S.; Brombacher, E. C.; Daetwyler, S.; Soneson, C.; Kresoja-Rakic, J.; Kocere, A.; Ronner, M.; Ernst, A.; Labbaf, Z.; Clouthier, D. E.; Firulli, A. B.; Sánchez-Iranzo, H.; Naganathan, S. R.; O’Rourke, R.; Raz, E.; Mercader, N.; Burger, A.; Felley-Bosco, E.; Huisken, J.; Robinson, M. D.; Mosimann, C.
    2022. Nature Communications, 13 (1), 1677. doi:10.1038/s41467-022-29311-7
  4. Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition
    Masek, M.; Etard, C.; Hofmann, C.; Hülsmeier, A. J.; Zang, J.; Takamiya, M.; Gesemann, M.; Neuhauss, S. C. F.; Hornemann, T.; Strähle, U.; Bachmann-Gagescu, R.
    2022. Nature Communications, 13 (1), 1282. doi:10.1038/s41467-022-28982-6Full textFull text of the publication as PDF document
  5. Genomic variations and epigenomic landscape of the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel
    Leger, A.; Brettell, I.; Monahan, J.; Barton, C.; Wolf, N.; Kusminski, N.; Herder, C.; Aadepu, N.; Becker, C.; Gierten, J.; Hammouda, O. T.; Hasel, E.; Lischik, C.; Lust, K.; Sokolova, N.; Suzuki, R.; Tavhelidse, T.; Thumberger, T.; Tsingos, E.; Watson, P.; Welz, B.; Naruse, K.; Loosli, F.; Wittbrodt, J.; Birney, E.; Fitzgerald, T.
    2022. Genome biology, 23 (1), Article no: 58. doi:10.1186/s13059-022-02602-4Full textFull text of the publication as PDF document
  6. The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel
    Fitzgerald, T.; Brettell, I.; Leger, A.; Wolf, N.; Kusminski, N.; Monahan, J.; Barton, C.; Herder, C.; Aadepu, N.; Gierten, J.; Becker, C.; Hammouda, O. T.; Hasel, E.; Lischik, C.; Lust, K.; Sokolova, N.; Suzuki, R.; Tsingos, E.; Tavhelidse, T.; Thumberger, T.; Watson, P.; Welz, B.; Khouja, N.; Naruse, K.; Birney, E.; Wittbrodt, J.; Loosli, F.
    2022. Genome biology, 23 (1), Article no: 59. doi:10.1186/s13059-022-02623-zFull textFull text of the publication as PDF document
  7. Examination of molecular hydrogen (H₂) treatment and electromagnetic field (EMF) radiation effects on the growth of animal (zebrafish embryos) and plant (Chlorella vulgaris). PhD dissertation
    Punampalam, R.
    2022, November 28. Karlsruher Institut für Technologie (KIT). doi:10.5445/IR/1000152185Full textFull text of the publication as PDF document
  8. Targeted deletion of Cd44 from pancreatic stellate cells impacts tumor growth. PhD dissertation
    Heneka, Y. M.
    2022, November 25. Karlsruher Institut für Technologie (KIT) 
  9. Untersuchung der Toxizität von Carbonfaser- und Quarzstäuben durch Exposition über ein air-liquid interface. PhD dissertation
    Friesen, A.
    2022, November 14. Karlsruher Institut für Technologie (KIT). doi:10.5445/IR/1000152391Full textFull text of the publication as PDF document
  10. Highly Fluorinated Peptide Probes with Enhanced In Vivo Stability for F‐MRI
    Meng, B.; Grage, S. L.; Babii, O.; Takamiya, M.; MacKinnon, N.; Schober, T.; Hutskalov, I.; Nassar, O.; Afonin, S.; Koniev, S.; Komarov, I. V.; Korvink, J. G.; Strähle, U.; Ulrich, A. S.
    2022. Small, 18 (41), Art.Nr. 2107308. doi:10.1002/smll.202107308Full textFull text of the publication as PDF document
  11. Genetically encodable fluorescent protein markers in advanced optical imaging
    Nienhaus, K.; Nienhaus, G. U.
    2022. Methods and Applications in Fluorescence, 10 (4), Art.-Nr.: 042002. doi:10.1088/2050-6120/ac7d3fFull textFull text of the publication as PDF document
  12. Droplet Microarray Based Screening Identifies Proteins for Maintaining Pluripotency of hiPSCs
    Liu, Y.; Bertels, S.; Reischl, M.; Peravali, R.; Bastmeyer, M.; Popova, A. A.; Levkin, P. A.
    2022. Advanced Healthcare Materials, 11 (18), Art.-Nr.: 2200718. doi:10.1002/adhm.202200718Full textFull text of the publication as PDF document
  13. Medaka as a model for seasonal plasticity: Photoperiod-mediated changes in behaviour, cognition, and hormones
    Lucon-Xiccato, T.; Montalbano, G.; Frigato, E.; Loosli, F.; Foulkes, N. S.; Bertolucci, C.
    2022. Hormones and Behavior, 145, Article no: 105244. doi:10.1016/j.yhbeh.2022.105244
  14. Characterisation and biological responses of inhalable aerosols from carbon fibres
    Mülhopt, S.
    2022. IAC Book of Abstracts 2022, 27 
  15. Deep-learning microscopy image reconstruction with quality control reveals second-scale rearrangements in RNA polymerase II clusters
    Hajiabadi, H.; Mamontova, I.; Prizak, R.; Pancholi, A.; Koziolek, A.; Hilbert, L.
    2022. (K. E. Nelson, Ed.) PNAS Nexus, 1 (3), 1–12. doi:10.1093/pnasnexus/pgac065Full textFull text of the publication as PDF document
  16. Gene Expression Profiling of Mono- and Co-Culture Models of the Respiratory Tract Exposed to Crystalline Quartz under Submerged and Air-Liquid Interface Conditions
    Friesen, A.; Fritsch-Decker, S.; Hufnagel, M.; Mülhopt, S.; Stapf, D.; Weiss, C.; Hartwig, A.
    2022. International Journal of Molecular Sciences, 23 (14), 7773. doi:10.3390/ijms23147773Full textFull text of the publication as PDF document
  17. Homodimerization Counteracts the Detrimental Effect of Nitrogenous Heme Ligands on the Enzymatic Activity of Acanthamoeba castellanii CYP51
    Nienhaus, K.; Sharma, V.; Nienhaus, G. U.; Podust, L. M.
    2022. Biochemistry, 61 (13), 1363–1377. doi:10.1021/acs.biochem.2c00198
  18. Characterisation of inhalable aerosols from carbon fibres
    Mülhopt, S.; Hauser, M.; Wexler, M.; Mahl, J.; Baumann, W.; Fritsch-Decker, S.; Weiss, C.; Friesen, A.; Hufnagel, M.; Hartwig, A.; Gutmann, B.; Schlager, C.; Krebs, T.; Goßmann, A.-K.; Weis, F.; Stapf, D.
    2022. 8th EFCA International Symposium on Ultrafine Particles - Air Quality and Climate. Abstract I.5, 52, European Federation of Clean Air and Environmental Protection Associations (EFCA) 
  19. Protein adsorption onto nanomaterials engineered for theranostic applications
    Nienhaus, K.; Xue, Y.; Shang, L.; Nienhaus, G. U.
    2022. Nanotechnology, 33 (26), Art.-Nr.: 262001. doi:10.1088/1361-6528/ac5e6c
  20. Comparing α-Quartz-Induced Cytotoxicity and Interleukin-8 Release in Pulmonary Mono- and Co-Cultures Exposed under Submerged and Air-Liquid Interface Conditions
    Friesen, A.; Fritsch-Decker, S.; Hufnagel, M.; Mülhopt, S.; Stapf, D.; Hartwig, A.; Weiss, C.
    2022. International Journal of Molecular Sciences, 23 (12), 6412. doi:10.3390/ijms23126412Full textFull text of the publication as PDF document
  21. A chemical probe for BAG1 targets androgen receptor-positive prostate cancer through oxidative stress signaling pathway
    Kuznik, N. C.; Solozobova, V.; Lee, I. I.; Jung, N.; Yang, L.; Nienhaus, K.; Ntim, E. A.; Rottenberg, J. T.; Muhle-Goll, C.; Kumar, A. R.; Peravali, R.; Gräßle, S.; Gourain, V.; Deville, C.; Cato, L.; Neeb, A.; Dilger, M.; Cramer von Clausbruch, C. A.; Weiss, C.; Kieffer, B.; Nienhaus, G. U.; Brown, M.; Bräse, S.; Cato, A. C. B.
    2022. iScience, 25 (5), Art.Nr. 104175. doi:10.1016/j.isci.2022.104175Full textFull text of the publication as PDF document
  22. RNA polymerase II clusters form in line with surface condensation on regulatory chromatin
    Hilbert, L.
    2022 
  23. Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts
    Schmaus, A.; Rothley, M.; Schreiber, C.; Möller, S.; Roßwag, S.; Franz, S.; Garvalov, B. K.; Thiele, W.; Spataro, S.; Herskind, C.; Prunotto, M.; Anderegg, U.; Schnabelrauch, M.; Sleeman, J.
    2022. Matrix Biology, 109, 173–191. doi:10.1016/j.matbio.2022.04.001
  24. High-Throughput Data Acquisition Platform for Multi-Larvae Touch-Response Behavior Screening of Zebrafish
    Wang, Y.; Kanagaraj, N. K.; Pylatiuk, C.; Mikut, R.; Peravali, R.; Reischl, M.
    2022. IEEE Robotics and automation letters, 7 (2), 858–865. doi:10.1109/LRA.2021.3134281
  25. Single molecule localization-based analysis of clathrin-coated pit and caveolar dynamics
    Ma, R.; Štefl, M.; Nienhaus, G. U.
    2022. Nanoscale Horizons, 7 (4), 385–395. doi:10.1039/D2NH00008C
  26. Anti-Inflammatory Characteristics of Local Anesthetics: Inhibition of TNF-α Secretion of Lipopolysaccharide-Stimulated Leucocytes in Human Blood Samples
    Weinschenk, S.; Weiss, C.; Benrath, J.; Baehr, V. von; Strowitzki, T.; Feißt, M.
    2022. International Journal of Molecular Sciences, 23 (6), Article no: 3283. doi:10.3390/ijms23063283Full textFull text of the publication as PDF document
  27. A Homozygous Missense Variant in PPP1R1B/DARPP-32 Is Associated With Generalized Complex Dystonia
    Khan, A.; Molitor, A.; Mayeur, S.; Zhang, G.; Rinaldi, B.; Lannes, B.; Lhermitte, B.; Umair, M.; Arold, S. T.; Friant, S.; Rastegar, S.; Anheim, M.; Bahram, S.; Carapito, R.
    2022. Movement disorders, 37 (2), 365–374. doi:10.1002/mds.28861
  28. Surface functionalisation-dependent adverse effects of metal nanoparticles and nanoplastics in zebrafish embryos
    Hansjosten, I.; Takamiya, M.; Rapp, J.; Reiner, L.; Fritsch-Decker, S.; Mattern, D.; Andraschko, S.; Anders, C.; Pace, G.; Dickmeis, T.; Peravali, R.; Rastegar, S.; Strähle, U.; Hsiao, I.-L.; Gilliland, D.; Ojea-Jimenez, I.; Ambrose, S. V. Y.; Belinga-Desaunay-Nault, M.-F. A.; Khan, A. O.; Lynch, I.; Valsami-Jones, E.; Diabaté, S.; Weiss, C.
    2022. Environmental science / Nano, 91 (1), 375–392. doi:10.1039/d1en00299f
  29. CEMIP, a Promising Biomarker That Promotes the Progression and Metastasis of Colorectal and Other Types of Cancer
    Domanegg, K.; Sleeman, J. P.; Schmaus, A.
    2022. Cancers, 14 (20), Art.Nr. 5093. doi:10.3390/cancers14205093Full textFull text of the publication as PDF document
  30. Conserved and diverged asymmetric gene expression in the brain of teleosts
    Agostini, C.; Bühler, A.; Antico Calderone, A.; Aadepu, N.; Herder, C.; Loosli, F.; Carl, M.
    2022. Frontiers in Cell and Developmental Biology, 10, Art.-Nr.: 1005776. doi:10.3389/fcell.2022.1005776Full textFull text of the publication as PDF document
  31. Phenotypic Discovery of Triazolo[1,5- c ]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype
    Wesseler, F.; Lohmann, S.; Riege, D.; Halver, J.; Roth, A.; Pichlo, C.; Weber, S.; Takamiya, M.; Müller, E.; Ketzel, J.; Flegel, J.; Gihring, A.; Rastegar, S.; Bertrand, J.; Baumann, U.; Knippschild, U.; Peifer, C.; Sievers, S.; Waldmann, H.; Schade, D.
    2022. Journal of Medicinal Chemistry, 65 (22), 15263–15281. doi:10.1021/acs.jmedchem.2c01199
  32. Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord
    Sánchez-Iranzo, H.; Halavatyi, A.; Diz-Muñoz, A.
    2022. eLife, 11, Art.-Nr.: e75429. doi:10.7554/eLife.75429Full textFull text of the publication as PDF document
  33. Highly Luminescent Positively Charged Quantum Dots Interacting with Proteins and Cells
    Wang, H.; Nienhaus, K.; Shang, L.; Nienhaus, G. U.
    2022. Chinese Journal of Chemistry, 40 (22), 2685–2693. doi:10.1002/cjoc.202200350Full textFull text of the publication as PDF document
  34. CEMIP ( HYBID , KIAA1199 ): structure, function and expression in health and disease
    Spataro, S.; Guerra, C.; Cavalli, A.; Sgrignani, J.; Sleeman, J.; Poulain, L.; Boland, A.; Scapozza, L.; Moll, S.; Prunotto, M.
    2022. The FEBS Journal. doi:10.1111/febs.16600Full textFull text of the publication as PDF document
  35. Pluripotency factors regulate the onset of Hox cluster activation in the early embryo
    Tiana, M.; Lopez-Jimenez, E.; de Aja, J. S.; Barral, A.; Victorino, J.; Badia-Careaga, C.; Rollan, I.; Rouco, R.; Santos, E.; Sanchez-Iranzo, H.; Acemel, R. D.; Torroja, C.; Adan, J.; Andres-Leon, E.; Gomez-Skarmeta, J. L.; Giovinazzo, G.; Sanchez-Cabo, F.; Manzanares, M.
    2022. Science Advances, 8 (28), 1–13. doi:10.1126/sciadv.abo3583Full textFull text of the publication as PDF document
  36. A DNA Segregation Module for Synthetic Cells
    Tran, M. P.; Chatterjee, R.; Dreher, Y.; Fichtler, J.; Jahnke, K.; Hilbert, L.; Zaburdaev, V.; Göpfrich, K.
    2022. Small, Art.-Nr.: 2202711. doi:10.1002/smll.202202711Full textFull text of the publication as PDF document
  37. Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements
    Baranasic, D.; Hörtenhuber, M.; Balwierz, P. J.; Zehnder, T.; Mukarram, A. K.; Nepal, C.; Várnai, C.; Hadzhiev, Y.; Jimenez-Gonzalez, A.; Li, N.; Wragg, J.; D’Orazio, F. M.; Relic, D.; Pachkov, M.; Díaz, N.; Hernández-Rodríguez, B.; Chen, Z.; Stoiber, M.; Dong, M.; Stevens, I.; Ross, S. E.; Eagle, A.; Martin, R.; Obasaju, O.; Rastegar, S.; McGarvey, A. C.; Kopp, W.; Chambers, E.; Wang, D.; Kim, H. R.; Acemel, R. D.; Naranjo, S.; Łapiński, M.; Chong, V.; Mathavan, S.; Peers, B.; Sauka-Spengler, T.; Vingron, M.; Carninci, P.; Ohler, U.; Lacadie, S. A.; Burgess, S. M.; Winata, C.; van Eeden, F.; Vaquerizas, J. M.; Gómez-Skarmeta, J. L.; Onichtchouk, D.; Brown, B. J.; Bogdanovic, O.; van Nimwegen, E.; et al.
    2022. Nature Genetics, 54, 1037–1050. doi:10.1038/s41588-022-01089-wFull textFull text of the publication as PDF document
  38. A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System
    Confino, S.; Dor, T.; Tovin, A.; Wexler, Y.; Ben-Moshe Livne, Z.; Kolker, M.; Pisanty, O.; Park, S. K.; Geyer, N.; Reiter, J.; Edvardson, S.; Mor-Shaked, H.; Elpeleg, O.; Vallone, D.; Appelbaum, L.; Foulkes, N. S.; Gothilf, Y.
    2022. International Journal of Molecular Sciences, 23 (4), Artkl.Nr.: 2373. doi:10.3390/ijms23042373Full textFull text of the publication as PDF document
  39. Loss of ASAP1 in the MMTV-PyMT model of luminal breast cancer activates AKT, accelerates tumorigenesis, and promotes metastasis
    Schreiber, C.; Gruber, A.; Roßwag, S.; Saraswati, S.; Harkins, S.; Thiele, W.; Foroushani, Z. H.; Munding, N.; Schmaus, A.; Rothley, M.; Dimmler, A.; Tanaka, M.; Garvalov, B. K.; Sleeman, J. P.
    2022. Cancer Letters, 533, Art.-Nr.: 215600. doi:10.1016/j.canlet.2022.215600
  40. Mandipropamid as a chemical inducer of proximity for in vivo applications
    Ziegler, M. J.; Yserentant, K.; Dunsing, V.; Middel, V.; Gralak, A. J.; Pakari, K.; Bargstedt, J.; Kern, C.; Petrich, A.; Chiantia, S.; Strähle, U.; Herten, D.-P.; Wombacher, R.
    2022. Nature chemical biology, 18 (1), 64–69. doi:10.1038/s41589-021-00922-3Full textFull text of the publication as PDF document
  41. mdka Expression Is Associated with Quiescent Neural Stem Cells during Constitutive and Reactive Neurogenesis in the Adult Zebrafish Telencephalon
    Lübke, L.; Zhang, G.; Strähle, U.; Rastegar, S.
    2022. Brain Sciences, 12 (2), Art.Nr. 284. doi:10.3390/brainsci12020284Full textFull text of the publication as PDF document
  42. Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells
    Ambrosi, G.; Voloshanenko, O.; Eckert, A. F.; Kranz, D.; Nienhaus, G. U.; Boutros, M.
    2022. eLife, 11. doi:10.7554/eLife.64498Full textFull text of the publication as PDF document
  43. Two plus one is almost three: a fast approximation for multi-view deconvolution
    Hüpfel, M.; Fernández Merino, M.; Bennemann, J.; Takamiya, M.; Rastegar, S.; Tursch, A.; Holstein, T. W.; Nienhaus, G. U.
    2022. Biomedical optics express, 13 (1), 147–158. doi:10.1364/BOE.443660Full textFull text of the publication as PDF document
  44. Early-life lead exposure induces long-term toxicity in the central nervous system: From zebrafish larvae to juveniles and adults
    Wang, Z.; Zhao, H.; Xu, Y.; Zhao, J.; Song, Z.; Bi, Y.; Li, Y.; Lan, X.; Pan, C.; Foulkes, N. S.; Zhang, S.
    2022. The science of the total environment, 804, Art.Nr. 150185. doi:10.1016/j.scitotenv.2021.150185