2022


Targeted deletion of Cd44 from pancreatic stellate cells impacts tumor growth. PhD dissertation
Heneka, Y. M.
2022, November 25. Karlsruher Institut für Technologie (KIT)
Development of a small molecule BAG1 inhibitor for estrogen receptor positive breast cancer therapy. PhD dissertation
Pan, M.
2022, December 1. Karlsruher Institut für Technologie (KIT). doi:10.5445/IR/1000152551
Conserved and diverged asymmetric gene expression in the brain of teleosts
Agostini, C.; Bühler, A.; Antico Calderone, A.; Aadepu, N.; Herder, C.; Loosli, F.; Carl, M.
2022. Frontiers in Cell and Developmental Biology, 10, Art.-Nr.: 1005776. doi:10.3389/fcell.2022.1005776
Phenotypic Discovery of Triazolo[1,5- c ]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype
Wesseler, F.; Lohmann, S.; Riege, D.; Halver, J.; Roth, A.; Pichlo, C.; Weber, S.; Takamiya, M.; Müller, E.; Ketzel, J.; Flegel, J.; Gihring, A.; Rastegar, S.; Bertrand, J.; Baumann, U.; Knippschild, U.; Peifer, C.; Sievers, S.; Waldmann, H.; Schade, D.
2022. Journal of Medicinal Chemistry, 65 (22), 15263–15281. doi:10.1021/acs.jmedchem.2c01199
Untersuchung der Toxizität von Carbonfaser- und Quarzstäuben durch Exposition über ein air-liquid interface. PhD dissertation
Friesen, A.
2022, November 14. Karlsruher Institut für Technologie (KIT). doi:10.5445/IR/1000152391
Characterisation of inhalable aerosols from carbon fibres
Mülhopt, S.
2022, July 5. 8th UFP Conference : International Symposium on Ultrafine Particles - Air Quality and Climate (2022), Brussels, Belgium, July 5–6, 2022
Medaka as a model for seasonal plasticity: Photoperiod-mediated changes in behaviour, cognition, and hormones
Lucon-Xiccato, T.; Montalbano, G.; Frigato, E.; Loosli, F.; Foulkes, N. S.; Bertolucci, C.
2022. Hormones and Behavior, 145, Article no: 105244. doi:10.1016/j.yhbeh.2022.105244
Characterisaton of inhalable aerosols from carbon fibres
Mülhopt, S.; Hauser, M.; Wexler, M.; Mahl, J.; Baumann, W.; Diabaté, S.; Fritsch-Decker, S.; Weiss, C.; Friesen, A.; Hufnagel, M.; Hartwig, A.; Gutmann, B.; Schlager, C.; Krebs, T.; Goßmann, A.-K.; Weis, F.; Stapf, D.
2022, September. 11th International Aerosol Conference (IAC 2022), Athens, Greece, September 4–9, 2022
Highly Luminescent Positively Charged Quantum Dots Interacting with Proteins and Cells
Wang, H.; Nienhaus, K.; Shang, L.; Nienhaus, G. U.
2022. Chinese Journal of Chemistry, 40 (22), 2685–2693. doi:10.1002/cjoc.202200350
Pluripotency factors regulate the onset of Hox cluster activation in the early embryo
Tiana, M.; Lopez-Jimenez, E.; de Aja, J. S.; Barral, A.; Victorino, J.; Badia-Careaga, C.; Rollan, I.; Rouco, R.; Santos, E.; Sanchez-Iranzo, H.; Acemel, R. D.; Torroja, C.; Adan, J.; Andres-Leon, E.; Gomez-Skarmeta, J. L.; Giovinazzo, G.; Sanchez-Cabo, F.; Manzanares, M.
2022. Science Advances, 8 (28), 1–13. doi:10.1126/sciadv.abo3583
Highly Fluorinated Peptide Probes with Enhanced In Vivo Stability for F‐MRI
Meng, B.; Grage, S. L.; Babii, O.; Takamiya, M.; MacKinnon, N.; Schober, T.; Hutskalov, I.; Nassar, O.; Afonin, S.; Koniev, S.; Komarov, I. V.; Korvink, J. G.; Strähle, U.; Ulrich, A. S.
2022. Small, 18 (41), Art.Nr. 2107308. doi:10.1002/smll.202107308
Genetically encodable fluorescent protein markers in advanced optical imaging
Nienhaus, K.; Nienhaus, G. U.
2022. Methods and Applications in Fluorescence, 10 (4), Art.-Nr.: 042002. doi:10.1088/2050-6120/ac7d3f
Droplet Microarray Based Screening Identifies Proteins for Maintaining Pluripotency of hiPSCs
Liu, Y.; Bertels, S.; Reischl, M.; Peravali, R.; Bastmeyer, M.; Popova, A. A.; Levkin, P. A.
2022. Advanced Healthcare Materials, 11 (18), Art.-Nr.: 2200718. doi:10.1002/adhm.202200718
Comparison of anxiety-like and social behaviour in medaka and zebrafish
Lucon-Xiccato, T.; Loosli, F.; Conti, F.; Foulkes, N. S.; Bertolucci, C.
2022. Scientific Reports, 12 (1), Art.Nr. 10926. doi:10.1038/s41598-022-14978-1
Deep-learning microscopy image reconstruction with quality control reveals second-scale rearrangements in RNA polymerase II clusters
Hajiabadi, H.; Mamontova, I.; Prizak, R.; Pancholi, A.; Koziolek, A.; Hilbert, L.
2022. (K. E. Nelson, Ed.) PNAS Nexus, 1 (3), 1–12. doi:10.1093/pnasnexus/pgac065
Characterisation of inhalable aerosols from carbon fibres
Mülhopt, S.; Hauser, M.; Wexler, M.; Mahl, J.; Baumann, W.; Fritsch-Decker, S.; Weiss, C.; Friesen, A.; Hufnagel, M.; Hartwig, A.; Gutmann, B.; Schlager, C.; Krebs, T.; Goßmann, A.-K.; Weis, F.; Stapf, D.
2022. 8th EFCA International Symposium on Ultrafine Particles - Air Quality and Climate. Abstract I.5, 52, European Federation of Clean Air and Environmental Protection Associations (EFCA)
Gene Expression Profiling of Mono- and Co-Culture Models of the Respiratory Tract Exposed to Crystalline Quartz under Submerged and Air-Liquid Interface Conditions
Friesen, A.; Fritsch-Decker, S.; Hufnagel, M.; Mülhopt, S.; Stapf, D.; Weiss, C.; Hartwig, A.
2022. International Journal of Molecular Sciences, 23 (14), 7773. doi:10.3390/ijms23147773
Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements
Baranasic, D.; Hörtenhuber, M.; Balwierz, P. J.; Zehnder, T.; Mukarram, A. K.; Nepal, C.; Várnai, C.; Hadzhiev, Y.; Jimenez-Gonzalez, A.; Li, N.; Wragg, J.; D’Orazio, F. M.; Relic, D.; Pachkov, M.; Díaz, N.; Hernández-Rodríguez, B.; Chen, Z.; Stoiber, M.; Dong, M.; Stevens, I.; Ross, S. E.; Eagle, A.; Martin, R.; Obasaju, O.; Rastegar, S.; McGarvey, A. C.; Kopp, W.; Chambers, E.; Wang, D.; Kim, H. R.; Acemel, R. D.; Naranjo, S.; Łapiński, M.; Chong, V.; Mathavan, S.; Peers, B.; Sauka-Spengler, T.; Vingron, M.; Carninci, P.; Ohler, U.; Lacadie, S. A.; Burgess, S. M.; Winata, C.; van Eeden, F.; Vaquerizas, J. M.; Gómez-Skarmeta, J. L.; Onichtchouk, D.; Brown, B. J.; Bogdanovic, O.; van Nimwegen, E.; et al.
2022. Nature Genetics, 54, 1037–1050. doi:10.1038/s41588-022-01089-w
Comparing α-Quartz-Induced Cytotoxicity and Interleukin-8 Release in Pulmonary Mono- and Co-Cultures Exposed under Submerged and Air-Liquid Interface Conditions
Friesen, A.; Fritsch-Decker, S.; Hufnagel, M.; Mülhopt, S.; Stapf, D.; Hartwig, A.; Weiss, C.
2022. International Journal of Molecular Sciences, 23 (12), 6412. doi:10.3390/ijms23126412
Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts
Schmaus, A.; Rothley, M.; Schreiber, C.; Möller, S.; Roßwag, S.; Franz, S.; Garvalov, B. K.; Thiele, W.; Spataro, S.; Herskind, C.; Prunotto, M.; Anderegg, U.; Schnabelrauch, M.; Sleeman, J.
2022. Matrix Biology, 109, 173–191. doi:10.1016/j.matbio.2022.04.001
Single molecule localization-based analysis of clathrin-coated pit and caveolar dynamics
Ma, R.; Štefl, M.; Nienhaus, G. U.
2022. Nanoscale Horizons, 7 (4), 385–395. doi:10.1039/D2NH00008C
Protein adsorption onto nanomaterials engineered for theranostic applications
Nienhaus, K.; Xue, Y.; Shang, L.; Nienhaus, G. U.
2022. Nanotechnology, 33 (26), Art.-Nr.: 262001. doi:10.1088/1361-6528/ac5e6c
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
Prummel, K. D.; Crowell, H. L.; Nieuwenhuize, S.; Brombacher, E. C.; Daetwyler, S.; Soneson, C.; Kresoja-Rakic, J.; Kocere, A.; Ronner, M.; Ernst, A.; Labbaf, Z.; Clouthier, D. E.; Firulli, A. B.; Sánchez-Iranzo, H.; Naganathan, S. R.; O’Rourke, R.; Raz, E.; Mercader, N.; Burger, A.; Felley-Bosco, E.; Huisken, J.; Robinson, M. D.; Mosimann, C.
2022. Nature Communications, 13 (1), 1677. doi:10.1038/s41467-022-29311-7
A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System
Confino, S.; Dor, T.; Tovin, A.; Wexler, Y.; Ben-Moshe Livne, Z.; Kolker, M.; Pisanty, O.; Park, S. K.; Geyer, N.; Reiter, J.; Edvardson, S.; Mor-Shaked, H.; Elpeleg, O.; Vallone, D.; Appelbaum, L.; Foulkes, N. S.; Gothilf, Y.
2022. International Journal of Molecular Sciences, 23 (4), Artkl.Nr.: 2373. doi:10.3390/ijms23042373
A chemical probe for BAG1 targets androgen receptor-positive prostate cancer through oxidative stress signaling pathway
Kuznik, N. C.; Solozobova, V.; Lee, I. I.; Jung, N.; Yang, L.; Nienhaus, K.; Ntim, E. A.; Rottenberg, J. T.; Muhle-Goll, C.; Kumar, A. R.; Peravali, R.; Gräßle, S.; Gourain, V.; Deville, C.; Cato, L.; Neeb, A.; Dilger, M.; Cramer von Clausbruch, C. A.; Weiss, C.; Kieffer, B.; Nienhaus, G. U.; Brown, M.; Bräse, S.; Cato, A. C. B.
2022. iScience, 25 (5), Art.Nr. 104175. doi:10.1016/j.isci.2022.104175
Anti-Inflammatory Characteristics of Local Anesthetics: Inhibition of TNF-α Secretion of Lipopolysaccharide-Stimulated Leucocytes in Human Blood Samples
Weinschenk, S.; Weiss, C.; Benrath, J.; Baehr, V. von; Strowitzki, T.; Feißt, M.
2022. International Journal of Molecular Sciences, 23 (6), Article no: 3283. doi:10.3390/ijms23063283
Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition
Masek, M.; Etard, C.; Hofmann, C.; Hülsmeier, A. J.; Zang, J.; Takamiya, M.; Gesemann, M.; Neuhauss, S. C. F.; Hornemann, T.; Strähle, U.; Bachmann-Gagescu, R.
2022. Nature Communications, 13 (1), 1282. doi:10.1038/s41467-022-28982-6
Loss of ASAP1 in the MMTV-PyMT model of luminal breast cancer activates AKT, accelerates tumorigenesis, and promotes metastasis
Schreiber, C.; Gruber, A.; Roßwag, S.; Saraswati, S.; Harkins, S.; Thiele, W.; Foroushani, Z. H.; Munding, N.; Schmaus, A.; Rothley, M.; Dimmler, A.; Tanaka, M.; Garvalov, B. K.; Sleeman, J. P.
2022. Cancer Letters, 533, Art.-Nr.: 215600. doi:10.1016/j.canlet.2022.215600
Genomic variations and epigenomic landscape of the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel
Leger, A.; Brettell, I.; Monahan, J.; Barton, C.; Wolf, N.; Kusminski, N.; Herder, C.; Aadepu, N.; Becker, C.; Gierten, J.; Hammouda, O. T.; Hasel, E.; Lischik, C.; Lust, K.; Sokolova, N.; Suzuki, R.; Tavhelidse, T.; Thumberger, T.; Tsingos, E.; Watson, P.; Welz, B.; Naruse, K.; Loosli, F.; Wittbrodt, J.; Birney, E.; Fitzgerald, T.
2022. Genome biology, 23 (1), Article no: 58. doi:10.1186/s13059-022-02602-4
The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel
Fitzgerald, T.; Brettell, I.; Leger, A.; Wolf, N.; Kusminski, N.; Monahan, J.; Barton, C.; Herder, C.; Aadepu, N.; Gierten, J.; Becker, C.; Hammouda, O. T.; Hasel, E.; Lischik, C.; Lust, K.; Sokolova, N.; Suzuki, R.; Tsingos, E.; Tavhelidse, T.; Thumberger, T.; Watson, P.; Welz, B.; Khouja, N.; Naruse, K.; Birney, E.; Wittbrodt, J.; Loosli, F.
2022. Genome biology, 23 (1), Article no: 59. doi:10.1186/s13059-022-02623-z
Mandipropamid as a chemical inducer of proximity for in vivo applications
Ziegler, M. J.; Yserentant, K.; Dunsing, V.; Middel, V.; Gralak, A. J.; Pakari, K.; Bargstedt, J.; Kern, C.; Petrich, A.; Chiantia, S.; Strähle, U.; Herten, D.-P.; Wombacher, R.
2022. Nature chemical biology, 18 (1), 64–69. doi:10.1038/s41589-021-00922-3
Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells
Ambrosi, G.; Voloshanenko, O.; Eckert, A. F.; Kranz, D.; Nienhaus, G. U.; Boutros, M.
2022. eLife, 11. doi:10.7554/eLife.64498
High-Throughput Data Acquisition Platform for Multi-Larvae Touch-Response Behavior Screening of Zebrafish
Wang, Y.; Kanagaraj, N. K.; Pylatiuk, C.; Mikut, R.; Peravali, R.; Reischl, M.
2022. IEEE Robotics and automation letters, 7 (2), 858–865. doi:10.1109/LRA.2021.3134281
Two plus one is almost three: a fast approximation for multi-view deconvolution
Hüpfel, M.; Fernández Merino, M.; Bennemann, J.; Takamiya, M.; Rastegar, S.; Tursch, A.; Holstein, T. W.; Nienhaus, G. U.
2022. Biomedical optics express, 13 (1), 147–158. doi:10.1364/BOE.443660
Surface functionalisation-dependent adverse effects of metal nanoparticles and nanoplastics in zebrafish embryos
Hansjosten, I.; Takamiya, M.; Rapp, J.; Reiner, L.; Fritsch-Decker, S.; Mattern, D.; Andraschko, S.; Anders, C.; Pace, G.; Dickmeis, T.; Peravali, R.; Rastegar, S.; Strähle, U.; Hsiao, I.-L.; Gilliland, D.; Ojea-Jimenez, I.; Ambrose, S. V. Y.; Belinga-Desaunay-Nault, M.-F. A.; Khan, A. O.; Lynch, I.; Valsami-Jones, E.; Diabaté, S.; Weiss, C.
2022. Environmental science / Nano, 91 (1), 375–392. doi:10.1039/d1en00299f
A Homozygous Missense Variant in PPP1R1B/DARPP-32 Is Associated With Generalized Complex Dystonia
Khan, A.; Molitor, A.; Mayeur, S.; Zhang, G.; Rinaldi, B.; Lannes, B.; Lhermitte, B.; Umair, M.; Arold, S. T.; Friant, S.; Rastegar, S.; Anheim, M.; Bahram, S.; Carapito, R.
2022. Movement disorders, 37 (2), 365–374. doi:10.1002/mds.28861
Early-life lead exposure induces long-term toxicity in the central nervous system: From zebrafish larvae to juveniles and adults
Wang, Z.; Zhao, H.; Xu, Y.; Zhao, J.; Song, Z.; Bi, Y.; Li, Y.; Lan, X.; Pan, C.; Foulkes, N. S.; Zhang, S.
2022. The science of the total environment, 804, Art.Nr. 150185. doi:10.1016/j.scitotenv.2021.150185